Photobiomodulation in the aging brain: a systematic review. Comprehensive review showingPBM effects on mitochondrial function, neuroinflammation, and cognition-related aging mechanisms

Transcranial photobiomodulation enhances working memory performance (Science Advances, 2022) Key takeaway: Human randomized study showing improved working memory after 1064
nm PBM.

Effects of transcranial photobiomodulation on functional brain networks in older adults (NeuroImage, 2025) Key takeaway: Imaging evidence of network modulation relevant to cognitive resilience.

Photobiomodulation therapy on the brain: mechanisms and pathways (2024) Key takeaway: Describes mitochondrial targets, ATP synthesis, redox signaling, and neuroplasticity.

World Association for Photobiomodulation Therapy — Dosage Recommendations Key
takeaway: Evidence-based dosage standards for safe, repeatable PBM use.

PBM stimulates mitochondrial activity, improves cellular metabolism and promotes neuronal repair. Evidence suggests PBM may reduce neurodegeneration and improve cognitive function in Alzheimer’s disease.

Transcranial PBM shows therapeutic potential for Alzheimer’s disease through mitochondrial stimulation, increased ATP production and reduced neuroinflammation.

Photomedicine and Laser Surgery Clinical data showed improvements in memory, attention and executive function in dementia patients treated with transcranial PBM.

Randomized controlled data suggests transcranial PBM improves motor function and neurological symptoms in Parkinson’s disease.

PBM may improve neurological function and motor control in Parkinson’s patients while maintaining a strong safety profile

PBM improved cognitive performance and neuropsychiatric symptoms in patients with post‑stroke cognitive impairment.

Journal: Neuroscience Letters / Clinical Studies
Summary: PBM enhances corticomotor excitability and may support motor recovery by promoting neuroplasticity after stroke.